MicroRNAs boost reprogramming, boot out cMyc
نویسندگان
چکیده
منابع مشابه
Temporal Requirements of cMyc Protein for Reprogramming Mouse Fibroblasts
Exogenous expression of Oct4, Sox2, Klf4, and cMyc forces mammalian somatic cells to adopt molecular and phenotypic characteristics of embryonic stem cells, commencing with the required suppression of lineage-associated genes (e.g., Thy1 in mouse). Although omitting cMyc from the reprogramming cocktail minimizes risks of uncontrolled proliferation, its exclusion results in fold reductions in re...
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© 2009, European Molecular Biology Organization This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 2.5 Generic License ( http://creativecommons.org/licenses/by-nc-nd/2.5/), which permits distribution, public display, and publicly performance, making multiple copies, provided the original work is properly cited. This license requ...
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ژورنال
عنوان ژورنال: Nature Reports Stem Cells
سال: 2009
ISSN: 1754-8705
DOI: 10.1038/stemcells.2009.62